abstract：:Environmental exposure to polychlorinated biphenyls (PCBs) is associated with an increased risk of incidence of metabolic disease, however the molecular mechanisms underlying this phenomenon are not fully understood. Our study provides new insights into molecular interactions between PCBs and retinoids (vitamin A and ...

journal_title：Toxicology and applied pharmacology

authors： Shmarakov IO,Lee YJ,Jiang H,Blaner WS

更新日期：2019-10-15 00:00:00

abstract：:Niclosamide is an antihelminthic drug used worldwide for the treatment of tapeworm infections. Recent drug repurposing screens have highlighted the broad bioactivity of niclosamide across diverse mechanisms of action. As a result, niclosamide is being evaluated for a range of alternative drug-repurposing applications,...

journal_title：Toxicology and applied pharmacology

authors： Vliet SMF,Dasgupta S,Sparks NRL,Kirkwood JS,Vollaro A,Hur M,Zur Nieden NI,Volz DC

更新日期：2019-10-01 00:00:00

abstract：:Lead (Pb) exposure at high concentrations is associated with poor sperm quality, acrosome alterations, and low fertilization rate. Sperm capacitation and the acrosome reaction (AR) are required for successful fertilization. Actin polymerization is crucial for correct capacitation, and small GTPases, such as RhoA, Rac1...

journal_title：Toxicology and applied pharmacology

authors： Godínez-Solís Y,Solís-Heredia MJ,Roa-Espitia A,Parra-Forero LY,Hernández-González EO,Hernández-Ochoa I,Quintanilla-Vega B

更新日期：2019-10-01 00:00:00

abstract：:Recent technological advances have moved the field of toxicogenomics from reliance on microarray platforms to high-throughput transcriptomic (HTTr) technologies that measure global gene expression. Gene expression biomarkers are emerging as useful tools for interpreting gene expression profiles to identify perturbatio...

journal_title：Toxicology and applied pharmacology

authors： Corton JC,Kleinstreuer NC,Judson RS

更新日期：2019-10-01 00:00:00

abstract：:Depression is one of the most common psychiatric disorders in the world. Andrographolide is a natural product that displays evident anti-inflammatory activities. The purpose of the present study was to explore the antidepressant potential of andrographolide in chronic unpredictable mild stress (CUMS)-induced depressiv...

journal_title：Toxicology and applied pharmacology

authors： Geng J,Liu J,Yuan X,Liu W,Guo W

更新日期：2019-09-15 00:00:00

abstract：:Arsenic-induced side effects limit its application in the treatment of acute promyelocytic leukemia (APL). We recently demonstrated that AS3MT 14215 (rs3740390) genotypes were associated with urinary arsenic metabolites and hematological and biochemical values. To further decipher the role of AS3MT genotypes on arseni...

journal_title：Toxicology and applied pharmacology

authors： Lu J,Yu K,Fan S,Liu W,Dong Z,Li J,Wang X,Hai X,Zhou J

更新日期：2019-09-15 00:00:00

abstract：:In many neuropathologies activated microglia and macrophages cause neurotoxicity and prolong the inflammatory response. We have previously characterized the glycosphingolipid Neurostatin (Nst), which potentially reduces these detrimental mechanisms. Nst, isolated from mammalian brain, is the GD1b ganglioside with O-ac...

journal_title：Toxicology and applied pharmacology

authors： Yanguas-Casás N,Ojalvo-Sanz AC,Martínez-Vázquez A,Goneau MF,Gilbert M,Nieto-Sampedro M,Romero-Ramírez L

更新日期：2019-08-15 00:00:00

abstract：:Allergic contact dermatitis (ACD) is caused by topical exposure to chemical allergens. Keratinocytes play a key role in innate immunity, as well as in ACD progression. The transmembrane Toll-like receptor 4 (TLR4), strongly implicated in skin inflammation, has the ability to bind Damage Associated Molecular Patterns (...

journal_title：Toxicology and applied pharmacology

authors： Kavasi RM,Berdiaki A,Spyridaki I,Papoutsidakis A,Corsini E,Tsatsakis A,Tzanakakis GN,Nikitovic D

更新日期：2019-08-15 00:00:00

abstract：:Air pollution, especially fine particulate matter (PM2.5, particles <2.5 μm in size), induces adverse health effects on the respiratory system. Uncontrolled proliferation of bronchial epithelial cells, resulting from deregulated cell cycle progression, contributes to pulmonary homeostatic imbalance. Although dysregula...

journal_title：Toxicology and applied pharmacology

authors： Xiao T,Ling M,Xu H,Luo F,Xue J,Chen C,Bai J,Zhang Q,Wang Y,Bian Q,Liu Q

更新日期：2019-08-15 00:00:00

abstract：:Deoxynivalenol (DON) is one of the most common mycotoxins which contaminate cereals and their by-products worldwide. Previous studies have stated toxic effects of DON on liver. Heme oxygenase-1 (HO-1) plays a potential role in protecting liver and maintaining gut microbiota homeostasis. Therefore, a study on the poten...

journal_title：Toxicology and applied pharmacology

authors： Peng Z,Liao Y,Chen L,Liu S,Shan Z,Nüssler AK,Yao P,Yan H,Liu L,Yang W

更新日期：2019-07-01 00:00:00

abstract：:Several large epidemiological and animal studies demonstrate a direct correlation between dietary heme iron intake and/or systemic iron levels and cancer risk in several cancers including colorectal cancer (CRC). However, the precise mechanisms for how heme iron contributes to CRC and how cancer cells respond to heme ...

journal_title：Toxicology and applied pharmacology

authors： Kim H,Yin K,Falcon DM,Xue X

更新日期：2019-07-01 00:00:00

abstract：:As the main toxic component of aristolochic acid, aristolochic acid I (AAI) is primarily found in Aristolochiaceae plants such as Aristolochia, Aristolochia fangchi and Caulis aristolochiae manshuriensis. AAI has been proven to be carcinogenic, mutagenic and nephrotoxic. Although the role of AAI in testicular toxicity...

journal_title：Toxicology and applied pharmacology

authors： Cui Y,Han J,Ren J,Chen H,Xu B,Song N,Li H,Liang A,Shen G

更新日期：2019-06-15 00:00:00

abstract：:Earlier, we reported that chronic cadmium (Cd)-exposure to prostate epithelial (RWPE-1) cells causes defective autophagy, which leads to the transformation of a malignant phenotype in both in vitro and in vivo models. However, the upstream events responsible for defective autophagy are yet to be delineated. The presen...

journal_title：Toxicology and applied pharmacology

authors： Kolluru V,Tyagi A,Chandrasekaran B,Ankem M,Damodaran C

更新日期：2019-06-15 00:00:00

abstract：:Tabun represents the phosphoramidate class of organophosphates that are covalent inhibitors of acetylcholinesterase (AChE), an essential enzyme in neurotransmission. Currently used therapy in counteracting excessive cholinergic stimulation consists of a muscarinic antagonist (atropine) and an oxime reactivator of inhi...

journal_title：Toxicology and applied pharmacology

authors： Kovarik Z,Maček Hrvat N,Kalisiak J,Katalinić M,Sit RK,Zorbaz T,Radić Z,Fokin VV,Sharpless KB,Taylor P

更新日期：2019-06-01 00:00:00

abstract：:The selenoprotein thioredoxin reductase (TXNRD) is a promising therapeutic target for cancer. To discover novel TXNRD inhibitors, a library of α, β-unsaturated carbonyl compounds were applied in structure-based virtual screening for the selection of hit compounds. Fifteen top-ranked compounds were further validated ex...

journal_title：Toxicology and applied pharmacology

authors： Liu R,Shi D,Zhang J,Li X,Han X,Yao X,Fang J

更新日期：2019-05-01 00:00:00

abstract：:Learning disabilities (LDs) in children are a serious global problem. Dibutyl phthalate (DBP), a plasticizer widely used in daily life, has been linked to triggering childhood LDs, however the mechanism underlying this remains unclear. Studies have shown that the ERK 1/2 pathway is closely related to apoptosis of hipp...

journal_title：Toxicology and applied pharmacology

authors： Yan B,Sun Y,Zeng J,Chen Y,Li C,Song P,Zhang L,Yang X,Wu Y,Ma P

更新日期：2019-04-01 00:00:00

abstract：:Catechol-O-methyltransferase (COMT) acts as a 'gate-keeper' to prevent DNA damage during estrogen metabolism. Both experimental and epidemiological studies suggest the role of COMT in pathogenesis of human breast cancer (BCa). It was previously reported that inhibition of COMT enzyme activity in estradiol-treated huma...

journal_title：Toxicology and applied pharmacology

authors： Wu Q,Odwin-Dacosta S,Cao S,Yager JD,Tang WY

更新日期：2019-03-15 00:00:00

abstract：:The anticancer drug ellipticine exerts its genotoxic effects after metabolic activation by cytochrome P450 (CYP) enzymes. The present study has examined the role of cytochrome P450 oxidoreductase (POR) and cytochrome b5 (Cyb5), electron donors to P450 enzymes, in the CYP-mediated metabolism and disposition of elliptic...

journal_title：Toxicology and applied pharmacology

authors： Reed L,Indra R,Mrizova I,Moserova M,Schmeiser HH,Wolf CR,Henderson CJ,Stiborova M,Phillips DH,Arlt VM

更新日期：2019-03-01 00:00:00

abstract：:Alteration in the expression pattern of Nrf-2 and NFκB has been reported in ulcerative colitis (UC) in which functional crosstalk between these two critical pathways has been suggested. The ameliorative potential of the AT1R blocker olmesartan (OLM) on oxidative stress and inflammatory cytokines has received considera...

journal_title：Toxicology and applied pharmacology

authors： Saber S,Khalil RM,Abdo WS,Nassif D,El-Ahwany E

更新日期：2019-02-01 00:00:00

abstract：:Nanotechnology is an emerging industry based on commercialization of materials with one or more dimensions of 100 nm or less. Engineered nanomaterials are currently incorporated into thin films, porous materials, liquid suspensions, or filler/matrix nanocomposites with future applications predicted in energy and catal...

journal_title：Toxicology and applied pharmacology

authors： Kane AB,Hurt RH,Gao H

更新日期：2018-12-15 00:00:00

abstract：:The issue of Elongated Mineral Particles (EMP) in building materials has been revealed during roadworks in 2013 in France. In fact, road coating aggregates are made of specific rock gravels that can contain Naturally Occurring Asbestos (NOA), which is mainly actinolite. The legislation refers to six regulatory asbesto...

journal_title：Toxicology and applied pharmacology

authors： Leocat E,Rielland C,Letessier P

更新日期：2018-12-15 00:00:00

abstract：:The length distributions of single fibrils of Coalinga, UICC-B and wet dispersed chrysotile were measured by transmission electron microscopy (TEM). It was found that the distributions significantly diverged above approximately 10 μm (μm) in length, corresponding to differences in published results of animal experimen...

journal_title：Toxicology and applied pharmacology

authors： Chatfield EJ

更新日期：2018-12-15 00:00:00

abstract：:The topobiological behaviour of Nrf1 dictates its post-translational modification and its ability to transactivate target genes. Here, we have elucidated that topovectorial mechanisms control the juxtamembrane processing of Nrf1 on the cyto/nucleoplasmic side of endoplasmic reticulum (ER), whereupon it is cleaved and ...

journal_title：Toxicology and applied pharmacology

authors： Xiang Y,Halin J,Fan Z,Hu S,Wang M,Qiu L,Zhang Z,Mattjus P,Zhang Y

更新日期：2018-12-01 00:00:00

abstract：:We investigated the potential effects of monosodium glutamate (MSG)-induced obesity with regards to nitric oxide and prostanoid production, as well as potassium channel function, in rat thoracic arteries. Newborn male Wistar rats were injected intraperitoneally with typically reported MSG (4.0 mg/g) once daily for 4 c...

journal_title：Toxicology and applied pharmacology

authors： Majewski M,Jurgoński A,Fotschki B,Juśkiewicz J

更新日期：2018-11-15 00:00:00

abstract：:Montelukast (MK),a cysteinyl leukotriene (CysLT1) receptor antagonist, latterly exhibited a remarkable neuroprotective activity in various neurodegenerative disorders. This study aims to elucidate the neuroprotective effect of MK in rotenone-induced Parkinson's disease(PD) model in rats. Ninety six male rats were spli...

journal_title：Toxicology and applied pharmacology

authors： Mansour RM,Ahmed MAE,El-Sahar AE,El Sayed NS

更新日期：2018-11-01 00:00:00

abstract：:Arsenic trioxide (ATO) has been reported to inhibit the activity of Ten-eleven translocation methylcytosine dioxygenase (TET). TET modulates FOXP3 expression, while dysregulation of FOXP3 expression promotes the malignant progression of leukemia cells. We examined the role of TET-FOXP3 axis in the cytotoxic effects of...

journal_title：Toxicology and applied pharmacology

authors： Chen YJ,Huang CH,Shi YJ,Lee YC,Wang LJ,Chang LS

更新日期：2018-11-01 00:00:00

abstract：:Copper (II) complexes are promising in the development of new synthetic models for cancer treatment. In this context, we synthesized a new copper complex containing the pharmacophore group 1,4-dioxo-2-butenyl, the Bis(((Z)-4-((4-chlorophenyl) amino)-4-oxobut-2-enoyl)oxy) copper compound and we evaluated its antitumor ...

journal_title：Toxicology and applied pharmacology

authors： de Oliveira EJT,Pessatto LR,de Freitas RON,Pelizaro BI,Rabacow APM,Vani JM,Monreal ACD,Mantovani MS,de Azevedo RB,Antoniolli-Silva ACMB,da Silva Gomes R,Oliveira RJ

更新日期：2018-10-01 00:00:00

abstract：:Although the precise etiology of Rheumatoid arthritis (RA) remains obscure, heightened immune response is thought to play a vital role in provoking joint inflammation and bone erosion. This study aims at comparatively evaluating the effects of two monoclonal antibodies Ranibizumab (RANI) as anti-VEGF antibody and Toci...

journal_title：Toxicology and applied pharmacology

authors： Abdel-Maged AE,Gad AM,Abdel-Aziz AK,Aboulwafa MM,Azab SS

更新日期：2018-10-01 00:00:00

abstract：:Non-small cell lung cancer (NSCLC) patients harboring EGFR mutation who initially respond to EGFR-TKI will gradually develop acquired resistance. There is still a challenge to treat EGFR-TKI resistant NSCLC patients. Polyphyllin I (PP I), a steroidal saponin isolated from Paris polyphylla., has been exhibited antitumo...

journal_title：Toxicology and applied pharmacology

authors： Yang Q,Chen W,Xu Y,Lv X,Zhang M,Jiang H

更新日期：2018-10-01 00:00:00

abstract：:Oxido-inflammatory aberrations play a substantial role in the pathophysiology of depression. Oxido-inflammatory stress increases catabolism of tryptophan into kynurenine which leads to imbalance in kynurenine and serotonin levels in the brain. Naringenin a flavonoid, has been reported to possess antidepressant propert...

journal_title：Toxicology and applied pharmacology

authors： Bansal Y,Singh R,Saroj P,Sodhi RK,Kuhad A

更新日期：2018-09-15 00:00:00

abstract：:Growing concern suggests that some chemicals exert (developmental) neurotoxicity (DNT and NT) and are linked to the increase in incidence of autism, attention deficit and hyperactivity disorders. The high cost of routine tests for DNT and NT assessment make it difficult to test the high numbers of existing chemicals. ...

journal_title：Toxicology and applied pharmacology

authors： Pamies D,Block K,Lau P,Gribaldo L,Pardo CA,Barreras P,Smirnova L,Wiersma D,Zhao L,Harris G,Hartung T,Hogberg HT

更新日期：2018-09-01 00:00:00

abstract：BACKGROUND:The aim of our study was to identify the genetic background of thiopurine-induced toxicity in a patient with a wild-type thiopurine methyltransferase genotype and activity. A 38-year-old Caucasian woman presented with cutaneous necrotizing vasculitis pancytopenia one month after starting azathioprine therapy...

journal_title：Toxicology and applied pharmacology

authors： Stiburkova B,Pavelcova K,Petru L,Krijt J

更新日期：2018-08-15 00:00:00

abstract：BACKGROUND:Perchloroethylene (perc) induced target organ toxicity has been associated with tissue-specific metabolic pathways. Previous physiologically-based pharmacokinetic (PBPK) modeling of perc accurately predicted oxidative metabolites but suggested the need to better characterize glutathione (GSH) conjugation as ...

journal_title：Toxicology and applied pharmacology

authors： Dalaijamts C,Cichocki JA,Luo YS,Rusyn I,Chiu WA

更新日期：2018-08-01 00:00:00

abstract：:Mice lacking the modifier subunit of glutamate cysteine ligase (Gclm), the rate-limiting enzyme in glutathione (GSH) synthesis, have decreased tissue GSH. We previously showed that Gclm-/- embryos have increased sensitivity to the prenatal in vivo ovarian toxicity of the polycyclic aromatic hydrocarbon benzo[a]pyrene ...

journal_title：Toxicology and applied pharmacology

authors： Lim J,Luderer U

更新日期：2018-08-01 00:00:00

abstract：:Side effects of methotrexate (MTX) especially hepatotoxicity limits clinical applications of this anticancer agent. Carboxypeptidase G2 (CPG2) is administrated for the treatment of elevated plasma concentrations of MTX. In this study, we have investigated the intracellular delivery of CPG2 fused to the transactivator ...

journal_title：Toxicology and applied pharmacology

authors： Sadeghian I,Khalvati B,Ghasemi Y,Hemmati S

更新日期：2018-05-01 00:00:00

abstract：:The Adverse Outcome Pathway (AOP) framework describes the progression of a toxicity pathway from molecular perturbation to population-level outcome in a series of measurable, mechanistic responses. The controlled, computer-readable vocabulary that defines an AOP has the ability to, automatically and on a large scale, ...

journal_title：Toxicology and applied pharmacology

authors： Pittman ME,Edwards SW,Ives C,Mortensen HM

更新日期：2018-03-15 00:00:00

abstract：:Berberine has been demonstrated to alleviate renal interstitial, liver and myocardial fibrosis when administered orally despite its extremely low bioavailability. Here, we inspected effect of berberine on pulmonary fibrosis (PF) and explored underlying mechanisms on the basis of intestinal endocrine. The results showe...

journal_title：Toxicology and applied pharmacology

authors： Guan C,Qiao S,Lv Q,Cao N,Wang K,Dai Y,Wei Z

更新日期：2018-03-15 00:00:00

abstract：:Although insulin and atorvastatin have been shown to exert glycemic control and could improve brain function, the effects of atorvastatin or insulin as well as the combination of atorvastatin plus insulin on brain pathology in diabetes mellitus type 1 (T1DM) are unclear. Therefore, this study investigated the effect o...

journal_title：Toxicology and applied pharmacology

authors： Pratchayasakul W,Thongnak LO,Chattipakorn K,Lungaphin A,Pongchaidecha A,Satjaritanun P,Jaiwongkam T,Kerdphoo S,Chattipakorn SC

更新日期：2018-03-01 00:00:00

abstract：:Defects in tryptophan metabolism on the l-kynurenine pathway (KP) are implicated in a number of human diseases, including chronic kidney disease, brain edema or injury, tuberculosis and malaria - as well as cancer, neurodegenerative and autoimmune disorders. However, it is unclear to what extent detrimental effects of...

journal_title：Toxicology and applied pharmacology

authors： Majewski M,Kasica N,Jakimiuk A,Podlasz P

更新日期：2018-02-15 00:00:00

abstract：:Ochratoxin A (OTA) is a mycotoxin that is found in various food and feed products. The molecular mechanisms that are associated with OTA hepatotoxicity and teratogenicity have not been extensively elucidated in a developing organism. In this study, the transcriptomic profile of zebrafish embryos indicates that hemosta...

journal_title：Toxicology and applied pharmacology

authors： Wu TS,Lin YT,Huang YT,Cheng YC,Yu FY,Liu BH

更新日期：2018-02-01 00:00:00